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In Print
Edited by Edward F. Domino, M.D., professor of pharmacology, and Tomoji Yanagita, M.D., Ph.D.: Japanese Michigan Fellows in Pharmacology. NPP Books, Ann Arbor, Michigan, in 1999.
David Ginsburg, Julian Hoff and Michael Marletta Named to the National Academy of Sciences’ Institute of MedicineThree noted researchers from the Medical School have been named to the National Academy of Sciences’ Institute of Medicine. David Ginsburg, M.D., Julian T. Hoff, M.D., and Michael A. Marletta, Ph.D., were among 55 new members in the U.S. named in 1999. They join approximately 20 U-M faculty, current and former, named to the 588-member body. Election to the Institute of Medicine, the medical arm of the National Academy of Sciences, is an honor reserved for those who have made major contributions to health and medicine or related fields. One-fourth of the members are drawn from outside the traditional health professions. Members volunteer their time on committees devoted to studies on a broad range of health policy issues.
Ginsburg has been cited as a leader in the effort to find the molecular genetic basis of human bleeding and clotting disorders. Notably, he has focused on the von Willebrand factor, or VWF, a protein central to the body’s blood coagulation system. About one percent of the general population may have an inherited bleeding disorder caused by abnormal VWF. Ginsburg’s work began with the cloning of the von Willebrand factor gene and now includes studies of how mutations in this gene lead to bleeding, and how mutations in other genes may also regulate VWF levels in the blood. Ginsburg and his team also research how blood clots are dissolved, and how abnormalities in this process contribute to human diseases including heart attack and stroke. Most recently, his studies identifying the cause of another inherited bleeding condition have revealed important new information about how many proteins, including clotting factors, are transported within and out of cells.
His Institute of Medicine nomination called Hoff a “triple threat” neurosurgery educator who combines clinical practice, teaching and research in a way that has brought him to national prominence and enabled him to influence the future of surgery. A clinical specialist in acoustic tumors, cervical spine surgery and brain tumors, Hoff has also conducted laboratory research on cerebral edema and intracerebral hemorrhage funded by the National Institutes of Health for 25 years. He has received two NIH neuroscience awards. His leadership activities in neurosurgery education include terms on the Residency Review Committee for Neurosurgery, as chairman of the American Board of Neurological Surgery, and as chair of task forces on neurosurgery resident education and fellowship. A past president of the American Association of Neurological Surgeons and of the American Academy of Neurological Surgeons, he is now president-elect of the Society of Neurological Surgeons, the principal society for neurosurgery educators, and second vice president of the American College of Surgeons. Marletta’s initial basic research on the biochemistry of nitrogen-containing compounds in the body has led to important knowledge about how cells send signals to one another, and has additional implications in toxicology. Specifically, his work on determining the biochemical precursor to nitrates and nitrites led to the discovery of a previously unknown metabolic pathway that produced the potent toxin nitrous oxide, or NO. These novel findings provided the basis for other researchers’ work on NO and Marletta’s analysis of the enzyme and chemical mechanism that result in NO formation in humans and other animals. His work was featured in the Spring 1999 issue of Medicine at Michigan. Nitrous oxide is now known to be an important signaling molecule in the body, but it was a mysterious one until Marletta and his colleagues solved the riddle of how it can send signals from one cell to another when its chemical reactivity with oxygen should cause it to decompose rapidly, preventing its function as a signaling agent. Further, his studies have shown how NO is able to signal without killing the cells that produce it. His work on the cellular receptor that captures NO molecules and keeps them from reacting with oxygen is important to the ongoing understanding of NO’s role in intercellular communication. These basic science discoveries have now led to NO’s being used clinically to treat pulmonary hypertension, and have suggested treatments for stroke, colitis and toxic shock syndrome.
1999 Honors Convocation AwardeesFollowing is a complete listing of all faculty and students who received awards at the 1999 Honors Convocation.
American Medical Women’s Association Gender Equity
Award
Association for Academic Surgery Student Research Awards Albert C. Furstenberg Award Edgar A. Kahn Award William Dodd Robinson Award Eli G. Rochelson Memorial Award Robert B. Sweet Award William B. Taylor Dermatology Award Harry A. Towsley Award Raymond W. Waggoner Award
George R. DeMuth Medical Scientist Award for Excellence Ralph M. Gibson Award Frank E. Ribbons Inteflex Award for Excellence in Scholarship
and Professional Development Andrew J. Zweifler Award for Excellence in Clinical Skills
Medical Center Alumni Society Scholarship-Service Award
Novartis Award for Outstanding Community Service
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Copyright 2001 University of Michigan Medical School
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Steven
R. Buchman, M.D., associate professor of surgery in
the section of plastic and reconstructive surgery, and
director of the Craniofacial Anomalies Program, won an
award for the “Best Paper of the Year” selected
from all the articles published in the Journal of Craniofacial
Surgery during the previous 12 months. The award for the
paper, “Use of Scanning Electron Microscopy in the
Evaluation of Craniosynostosis,” was presented to
Buchman at the 68th Scientific Meeting of the American
Society of Plastic and Reconstructive Surgeons in New
Orleans this past October.
Thomas
J. Carey, Ph.D., senior research scientist in the
Kresge Hearing Research Institute and the Department of
Otolaryngology, received the University of Michigan’s
Distinguished Research Scientist Award for 1999 in recognition
of his outstanding contribution to the intellectual environment
of the University. The Distinguished Research Scientist
Award was created as a testimony to the quality and dedication
of research scientists at the U-M. To reinforce and accentuate
the high prestige of the award, Carey has been granted
the official title of “Distinguished Research Scientist.”
Kathleen
L. Collins, M.D., Ph.D., assistant professor of internal
medicine and of microbiology and immunology, has been
named a 1999 Pew Scholar in the Biomedical Sciences. Collins
was one of only 20 Scholars chosen from nominations from
over 100 institutions in the U.S. The Pew Charitable Trusts
support nonprofit activities in the areas of conservation
and the environment, culture, education, health and human
services, public policy and religion. Collins was selected
for her promise as a biomedical researcher and will receive
a total award of $240,000 to help support her research
over a four-year period.
James
M. Cooke, M.D., co-chief resident and house officer
in the Department of Family Medicine, was selected to
attend the 1999 C. Everett Koop Residency Physician Leadership
Symposium. The Leadership Symposium is designed to promote
resident leadership and was held in September, 1999.
James
T. Elder, M.D., Ph.D., (Residency 1988) associate
professor of dermatology and of radiation oncology, has
been appointed to serve on the National Psoriasis Foundation’s
(NPF) Medical Advisory Board. The NPF Medical Advisory
Board counsels the NPF on technical and scientific matters
and provides guidance in effective application of the
organization’s resources in improving the medical
treatment and control of psoriasis and psoriatic arthritis.
David
Engelke, Ph.D., professor of biological chemistry
and director of the Program in Biomedical Sciences (PIBS),
has been chosen by the U.S. Department of Health and Human
Services to serve as chairperson of the Cell Development
and Function Study Section, Center for Scientific Review.
According to the NIH, “the skill and leadership offered
by the chairperson determine to a significant extent the
effectiveness and efficiency of the review group.”
Engelke will serve as chair through June 30, 2001.
Jameelah
Gater, a fourth-year student in the Medical School,
was elected student delegate to the American Academy of
Family Physicians Congress of Delegates. The AAFP Congress
is composed of two physician delegates from each of the
50 states and U.S. territories as well as two national
representatives from the following constituencies: new
physicians, women, uniformed services, residents, and
students. Representing the student voice for the nation,
Gater testified and voted on health care issues at the
annual congressional meeting in Florida in September,
1999. This new position also allows Gater to function
as a member of the National Committee on Resident and
Student Affairs (CRSA)which deals with issues ranging
from licensure to cultural diversity awareness and competency.
She is also active at the state level currently serving
on the Michigan Academy of Family Practice Board of Directors,
CRSA, and Statewide Student Day Planning Committee.
Janet
Gilsdorf, M.D., professor of pediatrics and communicable
diseases, received the third annual 1999 Journal of General
Internal Medicine Creative Writing Award for Prose for
her short story, “Off to the Left.” Gilsdorf’s
work was chosen from more than 70 submissions and was
published in the June 1999 issue (Vol. 14, No. 6). The
Journal of General Internal Medicine is the official journal
of the Society of General Internal Medicine.
Susan
Dorr Goold (M.D. 1987, Fellow 1992), assistant professor
of internal medicine, has received a four-year grant from
the Robert Wood Johnson Foundation for her research project
“Consumer Values and Preferences in Managed Care.”
The Robert Wood Johnson Foundation is the largest philanthropy
organization devoted exclusively to health and health
care.
Carmen
R. Green, M.D., assistant professor of anesthesiology
and director of the Acute Pain Service, was named the
Woman of the Year in Human Relations by the University
of Michigan’s Women of Color Task Force.
Lazar
J. Greenfield, M.D., Frederick A. Coller Distinguished
Professor and chair of surgery, has been elected secretary
general of the International Society for Cardiovascular
Surgery. The mission of the Society is to provide an international
forum for the presentation, discussion, and dissemination
of the state of the art and science of cardiovascular
disease and its treatment to those professionals.
Peter
Hedera, M.D. (Neurology Residency 1998), house officer
in medical genetics in the Department of Pediatrics and
Communicable Diseases, has received the Founders Award
of the Auxiliary of the American Academy of Neurology.
This award is designed to encourage clinical research
in neuroscience by physicians in clinical neurology training
programs. Hedera received this award for his genetic research
on hereditary spastic paraplegia.
Robert
B. Kiningham, M.D. (Residency 1992, Fellow 1993),
clinical assistant professor of family medicine and director
of the Primary Care Sports Medicine Fellowship, was named
a fellow of the American College of Sports Medicine. The
American College of Sports Medicine promotes and integrates
scientific research, education, and practical applications
of sports medicine and exercise science to maintain and
enhance physical performance, fitness, health and quality
of life.
Michael
S. Klinkman (M.D. 1982, Residency 1985), associate
professor of family medicine, received the 1998 Volunteer
Physician of the Year award from the Hope Medical Clinic
in Ypsilanti.
Arno
K. Kumagai, M.D., assistant professor of internal
medicine, was recently recognized as one of only 44 physicians
nationwide selected by medical students for the 1999 Association
of American Medical Colleges’ Humanism in Medicine
Award. Kumagai was nominated by the AAMC Organization
of Student Representatives as a physician embodying the
finest qualities in a healer who teaches healing. The
nomination stated that Kumagai “demonstrates an unusual
compassion and understanding of people and quickly puts
people at ease... he was always sensitive to patients’
needs and went out of his way to provide the highest quality
of care. It is no wonder that Dr. Kumagai has a very loyal
following of patients who often insist on seeing only
him as their diabetes health care specialist.”
Ralph
Lydic, Ph.D., Bert La Du Professor of Anesthesiology,
associate chair for anesthesia research and professor
of physiology, has been elected the 1999 president-elect
of the U.S. Sleep Research Society. The Sleep Research
Society’s mission is to promote understanding of
the processes of sleep and its disorders through research,
the training of practitioners of research, and the dissemination
of their research results to the scientific and medical
communities as well as the general public. Lydic’s
research ranges from transmembrane cell signaling to integrative
aspects of respiratory and arousal state control. These
studies aim to elucidate the cellular and molecular mechanisms
that cause respiratory depression during the loss of waking
consciousness. Lydic’s studies are funded by the
National Heart, Lung, and Blood Institute because of their
potential clinical relevance to disorders such as sudden
infant death syndrome, adult sleep apnea, and anesthesia-induced
respiratory depression.
The
December 9, 1999, issue of the Wall Street Journal featured
a commentary in the Leisure & Arts section by Howard
Markel, M.D., associate professor of pediatrics and
communicable diseases and director of the Historical Center
for the Health Sciences, and Ada Louise Huxtable. Entitled
"Ghosts of Hope and Despair: Ellis Island's Abandoned
Hospitals Are Crumbling Reminders of America's Immigrant
Story," the column was an urgent plea to save the
abandoned hospital buildings on Ellis Island, closed for
almost 50 years now, that tell their own story of immigrant
hope and despair. Markel and Huxtable are both among the
first group of fellows selected to do scholarly work for
a year at the Center for Scholars and Writers at the New
York Public Library. Huxtable is a noted architecture
critic.
Harold
Oberman, M.D. (Internship 1957, Residency 1961), professor
of pathology and director of the Blood Bank and Transfusion
Service, was given the Founders Award of the Michigan
Association of Blood Banks at its annual meeting on September
16, 1999.
Deborah
C. Otteson, a graduate student in the program for
cell and developmental biology working in the lab of Peter
Hitchcock, Ph.D., associate professor of ophthalmology
and visual sciences and of anatomy and cell biology, received
the Chapter Award from the Michigan Chapter for the Society
of Neurosciences for 1999 for her work, “Expression
patterns of IGF-I and IGF-I receptor mRNA suggest an autocrine/paracrine
role for IGF during retinal growth and regeneration in
goldfish.” Otteson presented her research at the
Society’s annual meeting held at the Fetzer Center
of Western Michigan University in May.
James Peggs, M.D., clinical associate professor
and senior associate chair in the Department of Family
Medicine, has been selected by the Michigan Academy of
Family Physicians as 1999 Family Practice Educator of
the Year.
Terrence
E. Steyer, M.D., Robert Wood Johnson Clinical Scholar
and lecturer of family medicine and internal medicine,
has been appointed to the Advisory Committee on Training
in Primary Care Medicine and Dentistry by U.S. Secretary
of Health and Human Services Donna Shalala.
Michael
Szymanski (M.D. 1979), clinical instructor in the
Department of Family Medicine, has been elected president
of the Michigan Academy of Family Physicians Foundation,
the philanthropic arm of the Michigan Academy of Family
Physicians.
Norman
W. Thompson (M.D. 1957, Residency 1962), Henry King
Ransom Professor and chief of the endocrine surgery section,
was given “Honorary Membership” in the Turkish
Association of Endocrine Surgery. Thompson was chosen
for this honor in recognition of his outstanding contributions
to the field of endocrine surgery. He has previously been
given honorary memberships in Scandinavian, British and
French associations of endocrine surgery.
John
Wiley, M.D. (Residency 1983, Fellow 1987), associate
professor of internal medicine and chief of gastroenterology
at the Veteran’s Administration Medical Center in
Ann Arbor, was honored with the Janssen Award for Research
in Digestive Disorders. Wiley was one of only 14 researchers
from around the world honored at the Fifth Annual Janssen
Awards in Gastroenterology in May, 1999. His research
focuses on the effects of aging on colonic function and
diabetes mellitus on sensory nerve function.
An
early participant in the electronic media revolution, a 5-year-old
U-M-based Web site dedicated to the concerns of transplant patients
now receives more than one million visits a month. Entitled
TransWeb: All About Transplantation and Donation, the site (www.transweb.org)
provides reliable information about all aspects of transplantation.
Users include transplant patients and their families, medical
professionals, and teachers and students. TransWeb’s mission
is to provide information about donation and transplantation
to improve organ and tissue procurement efforts worldwide, to
present information related to issues of concern to transplant
patients and their families, and to provide an index of sources
for transplant-related information. In September of 1999, Popular
Science ranked the TransWeb site one of the five best sites
on health and medicine in the world. Pictured above: TransWeb
Editor Eleanor Jones (center) and the TransWeb Editorial Board,
from left to right, Jeffrey Punch, M.D., assistant professor
of surgery; Jim Dean, senior programmer analyst; Robert Garypie,
organ preservation specialist; Robert Merion, M.D., associate
professor of surgery; and Alan Leichtman, M.D., associate professor
of internal medicine.
Recently
published books authored or edited by members of the University
of Michigan Medical School include:
David
Ginsburg, M.D., holds joint appointments in the U-M Medical
School’s Departments of Internal Medicine and Human Genetics
as the Warner-Lambert/Parke Davis Professor of Medicine, chief
of the Division of Molecular Medicine and Genetics and professor
of human genetics. He is also an investigator of the Howard
Hughes Medical Institute.
Julian
T. Hoff, M.D., is head of the Neurosurgery Section and professor
in the U-M Medical School Department of Surgery. He also heads
the Neurosurgery Training Program, one of the most sought-after
neurosurgery residencies in the nation.
Michael
A. Marletta, Ph.D., is the John G. Searle Professor of Medicinal
Chemistry in the U-M College of Pharmacy and a professor of
biological chemistry in the U-M Medical School, as well as a
Howard Hughes Medical Institute investigator. He also serves
as chair of the Biological Sciences Scholars Program in the
Medical School.
