Distinguished professor Martha Ludwig dies at 75
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Martha Ludwig, Ph.D., of the Department of Biological Chemistry and the Biophysics Research Division, died November 27, 2006, from complications of colon cancer. At the time of her death at age 75, she was the J. Lawrence Oncley Distinguished University Professor of Biological Chemistry.
Ludwig joined the U-M faculty in 1967. A distinguished X-ray crystallographer, Ludwig specialized in the structures of enzymes that employ the vitamins riboflavin and B12 as cofactors. Among her many contributions was the 1994 publication in Science of the first structure of vitamin B12 bound to a protein. During her postdoctoral training with future Nobel laureate William N. Lipscomb, Ph.D., she solved the structure of carboxypeptidase A, one of the first enzymes to be structurally characterized.
Her accomplishments resulted in many honors, including election to the National Academy of Sciences in 2003, and to the Institute of Medicine in 2006. She was a recipient of the Garvan Medal of the American Chemical Society, the U-M Distinguished Faculty Achievement Award, and was elected a fellow of the American Association for the Advancement of Science in 2001.
Ludwig is survived by her husband of 45 years, Frederic Hoch, M.D., emeritus professor of internal medicine and biological chemistry. Gifts in her memory may be directed to the Martha L. Ludwig Memorial Fund at the Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, 48109-0606.
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