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BURKE, David T., Ph.D.
Professor and Associate Research Scientist, Institute of Gerontology.- Molecular genetics, genome organization, and complex genetic trait analysis in the study of mammalian aging. Additional collaborative projects with faculty in the College of Engineering involve silicon microfabrication of nucleic acids analysis equipment.
BURMEISTER, Margit, Ph.D.
Professor of Human Genetics, Professor of Psychiatry, Research Professor, Mental Health Research Institute- Mouse and human behavorial genetics and neurogenetics.
CAMPER, Sally, Ph.D.
Professor and Chair of Human Genetics; Professor of Internal Medicine; Director, Transgenic Animal Model Core; Associate Director, Graduate Program in Biomedical Sciences- Development and function of the neuroendocrine system using transgenic mice, gene targeting, and molecular genetics analysis of mouse mutations.
CHAN, Raymond C., Ph.D.
Assistant Professor of Human Genetics and Internal Medicine- Our lab studies the establishment and maintenance of higher-order chromosome structures essential for accurate chromosome segregation. We apply biochemical, cell biological and genetics approaches in C. elegans to identify an characterize molecular factors required to properly package chromosomes during mitosis and meiosis.
DOUGLAS, Julie, Ph.D.
Assistant Professor of Human Genetics- Statistical genetics. Genetic mapping of complex human diseases and traits with an emphasis on the development, application, and evaluation of statistical methods.
FEARON, Eric R., M.D., Ph.D.
Professor of Internal Medicine, Human Genetics, and Molecular and Cellular Pathology; Associate Director for Basic Science, University of Michigan Comprehensive Cancer Center- Molecular genetics of cancer; identification and functional characterization of tumor suppressor genes in colorectal and breast cancer; and studies of the developmental function of tumor suppressor genes in mammalian and invertebrate systems. Key words: cancer biology, cancer genetics, colorectal cancer, breast cancer
GINSBURG, David, M.D.
Professor of Internal Medicine and of Human Genetics; Howard Hughes Investigator- Molecular genetics of inherited bleeding and thrombotic disorders. Areas of study include identification of novel genes regulating hemostasis by positional cloning approaches in human and mouse models, the development of transgenic and knockout mouse models for genetic disorders of blood coagulation, and molecular structure/function studies of key proteins within the complex regulatory pathways of hemostasis. Key words: human genetics, linkage anaylsis, hemostasis, blood coagulation, von Willebrand factor, factor V, fibrinolysis, thrombosis
GLASER, Thomas, M.D., Ph.D.
Associate Professor of Human Genetics and Internal Medicine- Molecular genetics of visual systems development, retinal cell fate determination, auditory hindbrain development, ribosomal protein disorders and tissue growth control.
GLOVER, Thomas W., Ph.D.
Professor of Human Genetics and Professor of Pediatrics- Molecular mechanisms of instability at chromosome fragile sites; developmental genetics of the lymphatic system; molecular biology of the Menkes disease gene and mammalian copper transport; studies of gene amplification in esophageal cancer. Key words: molecular cytogenetics, chromosome fragile sites, genome instability, gene mapping and cloning, Menkes disease, Progeria, copper homeostasis, Barrett's esophagus and esophageal cancer
GRUBER, Stephen B., M.D., Ph.D.
Associate Professor of Human Genetics; Associate Professor of Epidemiology; Associate Professor of Internal Medicine- Genetics epidemiology of cancer, focusing on gene-environment interactions; colorectal cancer; melanoma
HILDEBRANDT, Friedhelm, M.D.
Professor of Pediatrics and Human Genetics- Identification by postional cloning of genes causing monogenic kidney diseases, such as nephronophthisis and Bartter syndrome with deafness. The genes identified are functionally characterized through protein-protein interaction studies and generation of mouse models for the related human diseases.
INNIS, Jeffrey W., M.D., Ph.D.
Associate Professor of Human Genetics and Associate Professor of Pediatrics. - Molecular genetics of mammalian limb development; genetics of human limb malformation syndromes. Key words: molecular genetics, limb development, Hox genes, human genetics
KIM, John K., Ph.D.
Assistant Professor of Human Genetics; Research Assistant Professor, Life Sciences Institute- The Kim Lab studies how microRNAs and other emerging classes of small RNAs regulate fundamental biological processes, including heterochromatin formation, neuronal cell patterning, cardiac and skeletal muscle development, germline maintenance, and oncogenic cell proliferation. Using functional genomic, genetic, biochemical, and cell biology strategies, our lab investigates the molecular mechanisms of both the small RNAs and new candidate RNAi factors identified by genome-wide screens.
KOHRMAN, David, Ph.D.
Associate Professor and Associate Professor of Otolaryngology- Molecular genetics of inner ear structure and function, including analysis of the molecular basis of hearing loss and vestibular dysfunction in mice and humans.
LONG, Jeffrey, Ph.D.
Professor of Human Genetics and Adjunct Professor of Biostatistics- The research in this lab is focused on the analysis of human polymorphism, including human population genetics, the inheritance of complex diseases, and statistical genetics. One focus is on how levels of polymorphism and patterns of linkage disequilibrium are influenced by the interplay among diverse factors such as historical migrations, population size, gene flow, selective environment, mutation and recombination.
MARTIN, Donna, M.D., Ph.D.
Assistant Professor, Pediatrics and Communicable Diseases; Assistant Professor of Human Genetics- The genetic basis of central nervous system function in relation to disorders of human development. Specific interests in transcription factor function using mouse models of human disorders, neural and embryonic stem cells to study gene expression, neuronal differentiation and migration.
MEISLER, Miriam, Ph.D.
Professor of Human Genetics- Cloning and characterization of disease genes in mouse mutants and human patients. Mouse models of human inherited disorders, including epilepsy, dystonia, and neuromuscular disease. Comparative mapping of the human and mouse genomes. Key words: sodium channels, disease genes, mouse genetics, gene interaction, genome research
MORAN, John V., Ph.D.
Associate Professor of Human Genetics and Internal Medicine- Molecular analysis of human and mouse retrotransposons. Characterization of a novel retrotransposition mechanism. Studies of how transposable elements influence genomic diversity. Exploitation of human and mouse retrotransposons as genetic tools. Key words: transposons, L1 elements, genome evolution, spontaneous mutagens, molecular genetics, tissue cell culture, mechanistic studies
OMENN, Gilbert S., M.D., Ph.D.
Professor of Human Genetics and Internal Medicine; Director, Center for Computational Medicine and Biology- Application of informatics tools emerging from our National Center for Integrative Biomedical Informatics to cancer progression, diabetes, and other phenotypes; cancer proteomics; gene-environmental interactions.
PETTY, Elizabeth, M.D.
Associate Professor of Human Genetics and Associate Professor of Internal Medicine- Molecular genetic mechanisms underlying tumorigenesis with a focus on identifying and characterizing the roles of novel cancer genes and cell cycle checkpoint genes; clinical genetics research projects related to the cost-effect and ethical application of molecular genetic tests in medicine. Key Words: cancer, genetics, gene expression, cell cycle regulation, tumorigenesis
ROBINS, Diane M., Ph.D.
Professor of Human Genetics; Research Scientist for Reproductive Sciences Program- Molecular genetics of hormonal regulation; steroid hormone regulation of gene expression; androgen receptor function; prostate and breast cancer; sexually dimorphic liver gene expression; KRAB zinc finger repressor proteins. Key words: androgen, steroid hormone regulation, gene expression, breast cancer, prostate cancer.
ROSENBERG, Noah, Ph.D.
Assistant Professor of Human Genetics; Research Assistant Professor, Life Sciences Institute and Program in Bioinformatics- Human genetic variation and its role in the search for disease genes. The use of genetic markers to investigate human evolutionary history. Developing mathematical models and statistical tools for applications in population genetics.
SEKIGUCHI, JoAnn, Ph.D.
Assistant Professor of Human Genetics; Assistant Professor of Internal Medicine- Our lab studies mechanisms of DNA repair and how aberrant repair processes affect genomic stability, predisposition to cancer and immune system development.
SING, Charles F., Ph.D.
Professor of Human Genetics- Population and quantitative genetics; genetics of common diseases. Key words: heart disease, DNA sequencing, hypertension, genetic epidemiology, quantitative genetics.
STATES, David J., M.D., Ph.D.
Professor of Human Genetics; Research Professor, Bioinformatics Program- Computational analysis of genome regulatory elements. Techniques include simulation, classification, database construction and analysis, machine learning and parallel computation. Projects include: transcription factor binding site clusters, transcript reconstruction and analysis, genome contig assembly and analysis, megaclass sequence classification, and nucleosome binding modeling.
SWAROOP, Anand, Ph.D.
Professor of Human Genetics and Harold F. Falls Professor of Ophthalmology and Visual Sciences- Molecular genetics of age-related macular degeneration and retinitis pigmentosa; transcriptional regulation and signaling pathways underlying retinal differentiation and aging; and molecular pathways of cell death in retinal degenerative diseases.
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